The use of hand tools is still widely appreciated in industries at various levels. Hand tools application varies from a simple task like hammering to complicated, complex and precision-demanding tasks such as that of surgical scalpels. If a user works repeatedly and continuously with improper designed tool handle can suffers from cumulative trauma disorder (CTD).Hence, it becomes highly essential to design the tool handle for 'comfort' from the perspective of user. The aim of this study is to design a tool handle with maximum Grip quality for hammer in case of power grip. The focus of this study is mainly confined to identify the right cross-sectional diameters of the tool handle, based on optimizing the Grip quality function with the help of Genetic Algorithm technique. And a cross verification of results is also done by subjective experimentation of a group of subjects and find the approximate dimension which outstands in subject's perception of comfort. In this study, a new way of design a tool handle is to be introduced.